We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

What’s Next For AstraZeneca plc?

Where will AstraZeneca plc (LON:AZN) go from here?

| More on:

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Pfizer finally admitted defeat in its quest to acquire AstraZeneca (LSE: AZN) (NYSE: AZN.US) earlier this week. However, with Pfizer backing off, investors are now starting to ask questions about Astra’s future prospects. Specifically, investors want to know if Astra can meet its growth targets set out by management in the company’s defence against the US pharmaceutical giant.

That said, there is some speculation that Pfizer might return for another attempt after the six-month cooling-off period, or three months if Astra’s management invites Pfizer back to the table. On the other hand, with so much political opposition to the original deal, it’s likely that Pfizer won’t return with another offer anytime soon.

XXX

Lofty forecastsAstraZeneca

Now that Astra has rebuffed Pfizer, the company is going to have its work cut out to meet the lofty growth targets set out by management.

Indeed, Astra’s management turned down Pfizer’s offer as they believed that the company has the potential to achieve better returns for investors over the long term. Astra’s management has forecast that the company’s sales will increase by more than 75% over the next decade, returning to 2013 levels by 2017. 

There is no doubt that this forecast is optimistic and it is based on the success of a number of key drugs, which are currently under development. Actually, Astra is busy showcasing its emerging range of cancer drugs this week on a US roadshow. 

One of the treatments under development, with the most potential, uses anti-PD-L1 antibodies to target cancer cells. Some scientists believe that this treatment could prove as transformational as HIV drugs have been in tackling Aids; redefining the way that cancer patients are treated.

Raising concerns

Nevertheless, Astra’s forecasts are still just forecasts, and the company has to overcome some considerable barriers before it can market these potentially revolutionary drugs. 

For example, many more clinical trials are required before these new treatments can be sold to the public and there is also stiff competition from peers, Bristol-Myers Squibb, Roche, Novartis and Merck & Co.

When considering the barriers Astra still has to overcome, many City analysts believe that the company’s revenue forecasts are too optimistic. Actually, the company is targeting peak annual sales higher than even the most bullish analysts expect. There is a lot of talk that forecasts were inflated to boost the defence against Pfizer.

One of Astra’s top shareholders is so doubtful of these forecasts that it has called for the company’s pay policy to be linked to the spurned £55 price. 

Foolish summary

All in all, Astra has some potentially revolutionary treatments under development, which, if brought to market successfully, could transform the company’s future. 

Nevertheless, Astra still has a huge amount of work to do before these treatments get to market and the list of things that could go wrong is endless. What’s more, with legacy sales falling, Astra’s revenue is going to continue to slide until it gets these new treatments to market. 

Rupert does not own any share mentioned within this article.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »