We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Which is the better buy? GlaxoSmithKline plc vs Shire plc

Shire plc (LON: SHP) and GlaxoSmithKline plc (LON: GSK) are two very different companies, but which deserves your cash?

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Shire (LSE: SHP) and GlaxoSmithKline (LSE: GSK) are two of the UK’s premier pharmaceutical companies but over the past five years, their fortunes couldn’t have been more different.

While Shire’s explosive revenue and income growth has propelled the company’s shares higher, Glaxo has struggled to bring new products to the market and reignite sales growth. Specifically, this year City analysts are expecting a Shire to report revenue of just over $10bn, up a staggering 138% since 2011. Over the same period, the company’s earnings per share are on track to have grown by 158%. For 2017, City analysts have pencilled-in revenue growth of 36% and earnings per share growth of 19.2%.

XXX

Glaxo’s earnings per share are expected to grow by 27% this year bringing an end to four years of earnings declines as the company has struggled with falling sales. This year, City analysts are expecting the company to report revenue for the 12-month period of £27bn, which is £400m less than the figure reported for full-year 2011. Over the same period, if the company hits City targets this year, earnings per share will have declined by 19%.

Buy the underdog? 

After comparing these growth statistics between the two companies, it should come as no surprise that shares in Shire have outperformed those of Glaxo by 135% over the past five years.

Even though I’m usually attracted to the underdog, this time around it looks as if Shire may be the better long-term investment. Granted, Glaxo is returning to growth and the company’s dividend yield, which currently stands at 4.8% is attractive in today’s low-interest rate environment. Nonetheless, when it comes down to valuation, Glaxo looks less attractive than its smaller peer.

Shares in Glaxo currently trade at a forward P/E of 17.3, a valuation that looks rich at first glance but when you consider the company’s defensive nature and attractive dividend yield, it’s understandable. 

However, shares in Shire currently trade at a more attractive forward P/E of 15.6. City analysts are predicting that the company’s earnings per share will grow 79% this year, giving a PEG ratio of 0.2. A PEG ratio of less than one indicates that the shares in question offer growth at a reasonable price. Next year City analysts have pencilled-in earnings per share growth of 19% and on this basis shares in the company are trading at a 2017 P/E of 13.2.

As covered above, Glaxo’s earnings per share are expected to expand by 27% this year, but growth is projected to slow to 7% next year. The shares trade at a PEG ratio of 0.6 for 2016, which clearly shows that they’re less attractive than shares in Shire from a growth perspective.

The bottom line

So overall, while the allure of Glaxo’s market-beating dividend yield may draw investors to the company, Shire looks to be the better pick for growth.

Rupert Hargreaves owns shares of GlaxoSmithKline. The Motley Fool UK owns shares of and has recommended GlaxoSmithKline. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »