We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

If I had to buy just one FTSE 100 stock in 2024, it would be this

This Fool considered which FTSE 100 (INDEXFTSE:UKX) stock he’d buy next year if given only one choice. Here’s the champ he came up with.

| More on:
The Mall in Westminster, leading to Buckingham Palace

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

If I were made to buy just a single FTSE 100 stock next year, which one would it be? It’s a useful thought experiment because it forces me to consider all the qualities I really value in a stock. And with just one pick, I would prefer this share to tick all my boxes rather than just most.

Importantly, I wouldn’t be investing for just 2024. As a long-term investor, my holding period is five to 10 years, and ideally longer.

XXX

So here’s what I’m looking for:

  • A rock-solid competitive advantage
  • An attractive industry with permanent and growing demand
  • Exceptional management
  • Not obviously overvalued

After scanning up and down the Footsie, I’m plumping for AstraZeneca (LSE: AZN). Here’s why.

A quiet compounder

First, it’s noticeable that the stock rarely attracts the same financial media coverage or daily search volume of, say, Lloyds or Rolls-Royce. Yet with a market cap £155bn, AstraZeneca is over £100bn more valuable than both those blue-chips put together.

That’s not to say it gets no attention, of course. The healthcare stock is up around 190% in 10 years, excluding dividends. But I don’t think it’s had the fanfare it perhaps deserves given this exceptional performance.

Attractions

Medicines are in permanent demand, which makes them very recession-resistant. Yet due to the costs and regulation involved, the pharmaceutical industry has very high barriers to entry. This can make it an attractive industry to invest in.

AstraZeneca’s vast research budget and worldwide footprint give it a durable competitive advantage, in my view. It currently has more than 120 projects in Phase II/III development across oncology, rare diseases, and more. This huge pipeline should more than offset the inevitable clinical trial failures along the way.

Last year, the firm reported revenue of $44.3bn and $3.2bn in net income. However, those figures are poised to head higher as it enters new growth areas and the global population ages.

Source: AstraZeneca

Weight-loss market

The shares are trading at about 29 times trailing earnings. That’s less than peers Novo Nordisk (41) and Eli Lilly (107), two stocks that have boomed lately due to excitement around their respective weight-loss drugs.

Interestingly, however, AstraZeneca is also planning to enter this market after securing a licensing agreement for an oral weight-loss medicine. It hopes this pill could become a key differentiator to the current injectable alternatives.

The mushrooming weight-loss drug industry could be worth as much as $200bn within the next decade, according to Barclays. So it’s certainly one worth pursuing.

Now, one risk I’d highlight here is media speculation concerning the retirement of long-time chief executive Sir Pascal Soriot. Under his tenure, the drugmaker has been transformed into a forward-thinking, growth-oriented business.

Soriot has rubbished such reports as “fake news“. But could there really be smoke without fire? I’m not sure and he wouldn’t be easily replaced.

A head-scratching omission

Given my bullishness, why am I not already a shareholder?

To be honest, it’s a bit of a head-scratcher. Perhaps there’s always been something more alluring — a higher yield, faster growth — that has caught my eye. That’s a shame.

To make amends, I’m going to buy some AstraZeneca shares in 2024. They may not repeat their past outperformance, but I don’t think I’ll come to regret it down the line.

Ben McPoland has positions in Lloyds Banking Group Plc, Novo Nordisk, and Rolls-Royce Plc. The Motley Fool UK has recommended AstraZeneca Plc, Barclays Plc, Lloyds Banking Group Plc, and Novo Nordisk. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »