We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Down 51% in 2024, is this UK growth stock a buy for my Stocks and Shares ISA?

Ben McPoland considers Oxford Nanopore Technologies (LSE:ONT), a UK growth stock that has plunged over 80% since going public in 2021.

| More on:
Engineer Project Manager Talks With Scientist working on Computer

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Oxford Nanopore Technologies (LSE: ONT) is a growth stock I’ve considered a couple of times for my Stocks and Shares ISA. One of my sticking points though has been its high valuation.

But now the share price has fallen around 51% in 2024, I’m taking another look.

XXX

Innovative tech

The company has developed the world’s only nanopore DNA and RNA sequencing platform. This involves passing genetic material through tiny holes called nanopores (hence the firm’s name).

As the substance passes through these, it produces electrical signals that are used to decipher the sequence of DNA and RNA. And this method can result in real-time data for rapid insights.

Its portable MinION device is significantly smaller than traditional sequencing machines, offering greater flexibility. Researchers can use them in remote locations, thereby expanding the firm’s total addressable market.

Strong growth

In 2023, underlying life science research tools revenue grew 39% year on year to £170m, excluding legacy Covid-related contracts. Its active customer accounts increased 11% to over 7,600.

This is important because 74% of its revenue came from consumables last year. In other words, it makes most of its money providing supplies after it has sold a device — that’s a ‘razor-and-blades’ business model.

I like this model as it can result in serious profits. However, not for Oxford Nanopore… yet. It reported a £154.5m total loss for the year (much wider than 2022’s £91m loss).

Moreover, it moved its adjusted EBITDA breakeven target from 2026 to the end of 2027. This has likely weakened investor sentiment.

Looking ahead though, management is guiding for 20%-30% underlying revenue growth this year. And greater than 30% in the medium term. Therefore, the growth story is intact here.

Comparing stocks

The performance of two of its rivals hasn’t been much better recently. Shares of Pacific Biosciences of California are down 87% in the last year, while Illumina has shed over 40% of its value.

Created at TradingView

These competitors aren’t expecting much (if any) top-line growth in 2024, which makes Oxford Nanopore’s forecast growth appear even more impressive.

Looking at the price-to-sales (P/S) ratio though, the stock is more expensive (6.19) than these US peers.

Created at TradingView

That said, the forward-looking P/S multiple for 2024 drops to 4.9, which is more attractive.

Vultures circling

Unfortunately, investors today have little patience for firms with sales but only possible future profits. They want reliable profits now, and the business isn’t about to deliver this, so there’s a risk the shares drift even lower.

In this scenario, I think the company could become an acquisition target. It has world-class technology and a growing market opportunity.

We’ve just seen UK cybersecurity firm Darktrace snapped up. So we know private equity vultures are hovering.

Should I buy some shares?

I’ve had my fingers burnt lately investing in Moderna and Ginkgo Bioworks. They’re down between 30% and 50% so far for me. So I don’t have the stomach to invest in yet another loss-making healthcare stock.

However, if this wasn’t the case, I’d consider Oxford Nanopore stock after its 51% drop. It’s seeing increasing adoption of its devices across various research areas, while the market cap is just £833m.

The shares could rebound strongly if market sentiment changes or a bidder emerges — not that I’d ever buy purely on takeover speculation.

Ben McPoland has positions in Ginkgo Bioworks and Moderna. The Motley Fool UK has no position in any of the shares mentioned. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »