We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

2 potential buy-and-hold US stocks for the AI revolution

The AI revolution is in full swing, representing the single largest driver behind stock market performance. Dr James Fox explores two US stocks.

| More on:
Businessman hand stacking money coins with virtual percentage icons

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Artificial intelligence (AI) is transforming the global economy. But investors looking to gain exposure to this transformative sector will really need to look at US stocks. This is where the vast majority of the AI action is.

While chipmakers like Nvidia dominate headlines, the broader AI value chain stretches far beyond one company or sector. Two stocks I see as worth considering at opposite ends of that chain are Dutch semiconductor specialist ASML (NASDAQ:ASML) (traded in Europe and the US) and American software giant Salesforce (NYSE:CRM).

XXX

Supplying the picks and shovels

If AI is the new gold rush, ASML is selling the picks and shovels. The company is the world’s only manufacturer of extreme ultraviolet (EUV) lithography machines. This essential equipment is used to produce the most advanced semiconductors on the planet.

These cutting-edge chips are the backbone of AI infrastructure, powering data centres, model training, and edge deployment. Nvidia’s GPUs, AMD’s accelerators, and Apple’s in-house silicon all rely on chip foundries that use ASML’s EUV machines. Without EUV, there is no AI.

           

ASML’s machines are immensely complex, and the latest high NA (numerical aperture) EUV lithography machines cost around $380m. Barriers to entry are sky-high, and the firm has near-monopoly status in its niche. And while Chinese entities are trying to catch up, they appear to be a long way behind.

Risks? Well, ASML’s management recently disappointed the market with cautious guidance for 2026, stating they “cannot confirm growth in 2026” due to macroeconomic uncertainty and the impact of ongoing US-China trade tensions and tariff risks.

However, at 24 times forward earnings and with a price-to-earnings-to-growth (PEG) ratio of 1.49 — potentially cheap given its near-monopoly status — it’s certainly worth considering. I am watching very closely.

AI for enterprise

At the other end of the value chain sits Salesforce, a global leader in customer relationship management (CRM) software. Its products help businesses manage sales, marketing, service, and data. It’s now looking to be a leader in agentic AI.

Through its Einstein AI platform and new Copilot tools, Salesforce is automating workflows, generating insights, and enhancing productivity for customers across sectors. It’s not just about operational efficiency. This is about turning AI into a revenue-driving force within the enterprise.

           

What’s more, it also practices what it preaches. AI is accounting for 30% to 50% of the company’s own workload. Unlike hardware firms, Salesforce isn’t building chips or data centres. Instead, it’s applying AI where it counts: the user interface.

Moreover, with one of the world’s largest structured datasets on customer behaviour, and a sticky client base, the company is well-positioned to monetise AI over time.

There are risks, of course. The traditional enterprise solutions business is slowing and AI really is the way forward for Salesforce. One concern is whether Salesforce can use its strength to become the agentic AI market leader. And that’s always an issue with the likes of Microsoft around.

However, after a tough couple of years, Salesforce has refocused on profitability, cut costs, and improved free cash flow. It’s currently trading at 21 times forward earnings and with a PEG ratio of 1.2. I don’t think that’s too demanding and that’s why I believe investors should consider it. This stock is now a large part of my portfolio.

James Fox has positions in Advanced Micro Devices and Salesforce. The Motley Fool UK has recommended ASML, Advanced Micro Devices, Apple, Microsoft, and Salesforce. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »