We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Is this the FTSE 250’s best ‘unicorn’ stock?

The London Stock Exchange isn’t packed to the brim with what some call ‘unicorn’ stocks, but this FTSE 250 biotech firm looks highly interesting.

| More on:

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

The UK is not taking advantage of some very favourable business conditions. This is one of the biggest complaints about the modern state of the country. We have world-leading research hubs, three of the global top 10 universities, and the ability to attract the best talent. And where has it got us? Where are our dominant tech firms? Why aren’t the FTSE 100 and FTSE 250 bursting at the seams with market-disrupting startups? 

Our country’s under-representation in breakout companies makes for valid criticism. But a few do sneak past the challenging investment and regulatory hurdles and acquire that fabled ‘unicorn’ status — reaching $1bn in market cap. One example is exciting biotech firm Oxford Nanopore (LSE: ONT). 

XXX

Sequencing

So, what does the company do? And is it worth investing in? The name gives much of the game away. Oxford Nanopore was spun out of Oxford University in 2005. The company uses nanopore technology to sequence DNA and RNA. 

Anyone who took GCSE biology knows DNA is a long string of letters (A, T, G, and C). These can be read to derive the properties of living things. 

Well, the nanopore is a handheld device that allows DNA to be sequenced (or read) quickly and easily. This genetic material reading technology has use cases in health and industry. 

Among the many descriptions given in Oxford Nanopore’s investor information, the following quote struck me as an obvious example of where their sequencing devices might come in handy: “What are the differences between these tomato crops? How can we breed better varieties, that are more productive, long lasting or taste better? How can we apply this knowledge to a variety of plants from cereals to flowers?”

A buy?

Sadly, a useful product does not necessarily make a good company (or stock). A quick look at the numbers here tells a revealing story. Oxford Nanpore offered its shares at IPO at 615p. An initial flurry of activity spurred the shares up to a high of 710p before collapsing after that to a low of below a pound. Early investors have watched their holdings drop 66%. 

What happened here? Well, the company has posted losses in every year since IPO and revenue has stagnated too. Without a clear path to profitability or even growing sales, an early-stage growth stock does not look like the most attractive investment to me. 

The most promising outcome from here looks to be a rumoured takeover from a larger US firm (hey, I’ve heard that one before!). This rumour has propelled the shares to double since March. A premium paid in a takeover deal makes for a nice short-term bump, but as a long-term investor I think I’ll be steering clear.

John Fieldsend has no position in any of the shares mentioned. The Motley Fool UK has no position in any of the shares mentioned. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »