We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

‘FTSE 100 to reach 10,172!’ What are the best stocks to consider buying before the surge?

Updated analyst forecasts predict more growth’s on the horizon for the UK’s flagship index. But which stocks could benefit from this surge?

| More on:
Mature people enjoying time together during road trip

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

Despite reaching impressive new all-time highs, the FTSE 100 remains filled with fantastic stocks to buy, some even at a discount. And according to the latest projections from The Economy Forecast Agency, the UK’s flagship index may pass the coveted 10,000-point threshold by the end of 2025.

That’s less than three short months away, with an expected 7.3% increase for passive index investors, and possibly even more for stock pickers.

XXX

So for those looking to maximise their returns this year, which stocks should investors be considering ahead of this next potential surge?

Finding the best stocks in October

While the stock market’s outperforming, the British economy’s in a bit of a tight spot. Inflation is proving stickier than expected, growth’s proving elusive, and the delayed government Autumn Budget is only adding to the uncertainty.

Therefore, when hunting for the best investment opportunities right now, I think it’s prudent for investors to search for the firms that:

  1. Have a strong balance sheet.
  2. Aren’t solely dependent on the UK for revenue.
  3. Enjoy continuous demand from customers regardless of economic conditions.

While these are certainly not the only important factors, they serve as a helpful filter to avoid a large number of traps. And luckily, the London Stock Exchange is home to many companies that pass these requirements. In fact, most of them are large-cap stocks in the FTSE 100, potentially explaining the bullish forecast from the experts.

A large-cap to consider?

Perhaps a perfect example of an international titan with strong financials and consistent demand is AstraZeneca (LSE:AZN).

As a near-£200bn enterprise, it certainly has size on its side. And being a global leading biopharma business specialising in cancer, cardiovascular, respiratory, and rare disease therapies, revenue has been pretty consistent even during the worst economic downturns. After all, even during a recession, people still need access to medicine.

The company’s been on a bit of a rampage of late. There are legitimate concerns of upcoming patent expirations, but the group’s on a bit of a winning streak when it comes to clinical trial results.

Numerous phase 3 drug candidates are reporting encouraging results, some capable of potentially turning into new blockbusters, replacing lost revenue from patent expirations and delivering even more. In fact, the excitement surrounding AstraZeneca’s Efzimfotase Alfa – a novel enzyme replacement therapy – is one of the reasons why Goldman Sachs recently raised its share price target to £150.13.

If this forecast proves accurate, that’s a potential 17.5% capital gain paired with a welcome 1.9% dividend yield.

Taking a step back

The outlook for AstraZeneca shares looks exceptionally promising. However, like all forecasts, investors need to add in a healthy dose of scepticism.

I’ve already mentioned the risks associated with upcoming patent expirations. However, there are also other threats to consider.

Regulatory pricing changes in the US – AstraZeneca’s core market – could adversely impact margins, particularly among its flagship oncology treatments. So even if revenue growth meets expectations, earnings could still disappoint.

It’s also important to highlight that AstraZeneca isn’t short on competitors, many of whom are developing their own treatments to protect and steal market share.

Nevertheless, with an impressive drug pipeline and proven track record, investors hunting for top-notch stocks may want to investigate further.

Zaven Boyrazian has no position in any of the shares mentioned. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »