We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The largest S&P 500 holding in my ISA is…

Edward Sheldon’s making a large bet on this S&P 500 stock. Because he sees the long-term risk/reward proposition very attractive.

| More on:
The flag of the United States of America flying in front of the Capitol building

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

The S&P 500 index has been an incredible wealth generator over the last decade. Personally, I’ve made big gains on a number of stocks in the index including Apple, Alphabet, and Nvidia.

As for my largest S&P 500 holding today, it’s a Mag 7 stock. But it’s not one of the names mentioned above.

XXX

A tech powerhouse

Instead, it’s Amazon (NASDAQ: AMZN). This is the company I’m most confident in from a long-term risk/reward perspective.

What I love about Amazon is that it’s a really diversified business. Ultimately, it’s a technology conglomerate. Everyone knows that it’s a powerhouse in e-commerce. This division underpins the group, generating a huge amount of cash flow for the company every year (group operating cash flow last year was $140bn).

One competitive advantage the company has here is that it has hundreds of millions of Prime members. These customers (myself included) tend to do a lot of shopping on the platform.

Looking beyond e-commerce, Amazon’s the largest player globally in cloud computing. This division continues to generate strong growth (24% growth in Q4 2025).

Note that in the years ahead, the cloud computing industry is expected to see rapid growth due to the AI revolution. So Amazon has some powerful tailwinds here.

A major player in AI

Speaking of AI, Amazon’s a big player here. A good example is its AI chips. In its recent annual letter, the company said that if it was selling its chips to third parties, it would be generating annual revenue of around $50bn. In other words, it’s fast becoming a major competitor to Nvidia.

It’s also worth pointing out that Amazon’s a major investor in AI powerhouse Anthropic. It owns around 15%-20% of this company.

Digital advertising growth

Additionally, Amazon’s a dominant force in digital advertising. Today, it’s the third largest player behind Alphabet and Meta. In Q4, this area of the business grew 22% year on year to $21bn. So this is a whole new growth driver for the group.

Space revenues

One other area of the business worth mentioning is space. Over the last decade, Amazon’s built its own low earth orbit satellite network with more than 200 satellites.

This is scheduled to launch in mid-2026. However, already the company has meaningful revenue commitments from the likes of Delta Airlines, NASA, and Vodafone.

Many ways to win

Looking beyond all this, Amazon’s also a force in robotics (it has over a million robots operating in its factories), self-driving cars (its Zoox cars are in operation in the US today), and digital healthcare (its platform now offers weight-loss drugs).

So overall, it has many ways to win. That’s one of the reasons I see the risk/reward skew as attractive.

Another is the valuation. Today, the stock trades on a mid-20s price-to-earnings ratio. I see that multiple as very reasonable given the long-term growth potential. That’s why I’m comfortable with a large position.

Worth a look?

Of course, there are plenty of risks. One is in relation to the amount of money the company’s spending on AI ($200bn this year) – it may not pay off. Another is a consumer slowdown. This could hurt e-commerce growth.

Overall though, I’m very bullish here. I think Amazon’s worth a closer look today.

But it’s not the only S&P 500 name I like right now…

Edward Sheldon has positions in Amazon, Apple, Alphabet, and Nvidia. The Motley Fool UK has recommended Alphabet, Amazon, Apple, Meta Platforms, Nvidia, and Vodafone Group Public. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »