We have some exciting news to share! The Motley Fool UK has now become The Twelfth Magpie -- an independent, UK-owned company, led by our long-serving UK management team — Mark Rogers, Chris Nials and Heather Adlington. In practical terms, it’s the same team you know, now fully focused on serving our UK readers and members.

Just as importantly, our approach remains unchanged: long-term, jargon-free, and on your side. This site is our new home, and there will be extra tweaks made across the coming few days as we settle in. So if anything looks a little off, please bear with us!

The content of this article was relevant at the time of publishing. Circumstances change continuously and caution should therefore be exercised when relying upon any content contained within this article.

Why I Think Shire plc Will Outperform AstraZeneca plc And GlaxoSmithKline plc By At Least 10% In 2015

Alessandro Pasetti explains why Shire plc (LON:SHP) is his favourite pick, followed by GlaxoSmithKline plc (LON:GSK), and why he’d avoid AstraZeneca plc (LON:AZN) for some time.

| More on:

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More.

You probably know everything about GlaxoSmithKline (LSE: GSK) (NYSE: GSK.US) by now: a bribery scandal in China, falling earnings and a patent cliff have all weighed on its equity valuation in recent times. You’ll surely also have heard of AstraZeneca (LSE: AZN) (NYSE: AZN.US): its revenue and earnings have dropped at a faster clip, but Astra’s valuation has been favoured by a takeover approach from Pfizer last year. 

If I were to invest in the pharma space, though, I’d probably choose Shire (LSE: SHP), which will comfortably outperform Glaxo and Astra this year and next, in my view. Here’s why.

XXX

GlaxoSmithKline: It Could Get Better 

I have been very bullish on Glaxo until recently but its fundamentals, a conservative corporate strategy, its pipeline of drugs as well as the stock’s relative valuation suggest that Glaxo won’t deliver huge capital gains for some time, although its dividend yield is particularly appealing. Upside is in the region of 10% in 2015, in my opinion. 

“GSK faces a load of problems of its own. It’s a huge player in respiratory, which is facing precisely the same issues as diabetes for Sanofi – massive price pressure, basically turning it into a commodity segment,” one senior pharma analyst recently told me. “And GSK sold its oncology business to Novartis, which is seen as lunacy, (given that) oncology is probably the biggest growth area now for pharma,” he added. 

The average price target from brokers has declined by 15% in the last 12 months to 1,505p, which is 9% higher than Glaxo’s current valuation of 1,377p. Analysts at JP Morgan took the brave decision to cut Glaxo’s price target to 1,300p (underweight, from neutral) earlier this week, but I think the shares could easily beat consensus estimates by the end of the year. 

A soft break-up of the group would be great news for value investors. 

AstraZeneca: Simply Overpriced

Astra is my least favourite pick in the pharma sector, although Astra’s management team has done a good job in managing expectations in recent times. 

Based on trading multiples, fundamentals, R&D and the pipeline of drugs, my price target for Astra is much lower than Astra’s current equity valuation — say between £30 and £35 a share, for an implied downside of up to 33% from its current level. I appreciate Astra offers a decent yield, but roughly one third of its current stock market value is still based upon hopes that a suitor will show up with a blown-out offer, which is highly unlikely in my view. 

JP Morgan raised its price target to 4,500p this week, which is about 6% below the average price target from brokers. I think most analysts are wrong, end of story. 

Shire: Lots To Like In It At This Price

At 4,560p, Shire shares seem properly priced right now, one may argue. Following the integration of ViroPharma, additional bolt-on deals may boost shareholder value, however.

Shire stock has depreciated fast in recent months, but may surge if Shire exploits its strong balance sheet. According to press reports, the British company is one of the few bidders lined up for NPS Pharmaceuticals, which would be a good fit in Shire’s portfolio. Since merger talks with AbbVie collapsed, the shares of Shire have lost 15% of value, but a strong pipeline of drugs may also help it deliver a strong growth rate for revenue and earnings over the medium term.

I’d add Shire to a diversified portfolio based on fundamentals and trading metrics, which indicate upside could be at least 20% in the next 12 months or so.

If Shire managers get their capital allocation strategy right (I have little doubt they will), I may end up agreeing — for once! — with analysts at Citi and JP Morgan, who raised Shire’s price target to over 5,000p earlier this week.

Alessandro Pasetti has no position in any shares mentioned. The Motley Fool UK has recommended GlaxoSmithKline. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors.

More on Investing Articles

Friends and sisters exploring the outdoors together in Cornwall. They are standing with their arms around each other at the coast.
Investing Articles

£503 buys 14 shares in this FTSE 250 stock that returned 23.9% annually for the last 15 years

This FTSE 250 stock has averaged a huge return for 15 years. At today's price, £503 buys 14 shares. But…

Read more »

Black woman using loudspeaker to be heard
Investing Articles

£1,000 buys 25 shares in this FTSE 100 stock that’s returned 29.2% annually for the last 10 years

This FTSE 100 mining stock has returned close to 30% a year for a decade. At 3,995p, £1,000 buys 25…

Read more »

Female student sitting at the steps and using laptop
Investing Articles

Down 47%, is this growth stock finally worth buying in May?

With a £288m order book and a hidden pipeline of defence and nuclear contracts, is this growth stock now too…

Read more »

House models and one with REIT - standing for real estate investment trust - written on it.
Investing Articles

2 REITs yielding 7%+ to consider for passive income in 2026

A REIT backed by the NHS and another backed by Tesco and Sainsbury's with both yielding 7%+. Here's why I'm…

Read more »

Woman riding her old fashioned bicycle along the Beach Esplanade at Aberdeen, Scotland.
Investing Articles

Just 97 shares of this UK dividend stock generate £238 in passive income

A 5.7% yield, £238 in passive income from just 97 shares, and one of the most divisive dividend stocks on…

Read more »

ISA coins
Investing Articles

£10,000 in an ISA generates a second income of…

The London Stock Exchange is home to some of the world's most generous dividends. But how big a second income…

Read more »

Shot of a senior man drinking coffee and looking thoughtfully out of a window
Investing Articles

Expert recommendations: 2 top income stocks yielding 7%+!

With yields of 7.2% and 7.8% respectively, these two income stocks are catching the eyes of institutional analysts. Should investors…

Read more »

Illustration of flames over a black background
Investing Articles

3 top income-focused stocks to buy in May 2026, according to experts

Looking for a stock to buy for income in May 2026? Experts have flagged these three UK dividend shares as…

Read more »